Biologics : Hidden Gems
Overview
Biologics: Discovering promising molecules with untapped market potential, not yet pursued by both big pharma and smaller players.
Obinutuzumab
Developer: Roche
Indications: Chronic lymphocytic leukemia (CLL), Follicular Lymphoma (FL)
Patent Expiry: 2024
Therapy Duration: 6 cycles (6 months)
Dosing:
- CLL: Administered three times in the first month, followed by monthly doses.
- FL: Administered over six cycles.
Cost (India):
- Per Vial: INR 2.1 Lac
- Total Cost of Therapy in 2024: INR 14.7 Lac
- Forecast Cost of Therapy: INR 4.9 Lac
Ramucirumab
Developer: Novartis
Indications: Gastric Cancer
Patent Expiry: 2024
Therapy Duration: 4 cycles (4 months)
Dosing: Administered every two weeks.
Cost (India):
- Per Vial: INR 80 K
- Total Cost of Therapy in 2024: INR 6.4 Lac
- Forecast Cost of Therapy: INR 2.1 Lac
Ipilimumab
Developer: Bristol-Myers Squibb (BMS)
Indications: Non-Small Cell Lung Cancer (NSCLC), Renal Cell Carcinoma, Colorectal Cancer, Hepatocellular Carcinoma
Patent Expiry: 2024
Dosing:
- NSCLC: Administered every 3 weeks for 23 months.
- Renal Cell Carcinoma: 4 doses at 1mg/kg.
- Colorectal Cancer: 4 doses at 1 mg/kg.
- Hepatocellular Carcinoma: 4 doses at 3mg/kg.
Cost (India):
- Per Vial: INR 1.8 Lac
- Total Cost of Therapy in 2024: INR 2.7 Lac (NSCLC), INR 9 Lac (Hepatocellular Carcinoma)
- Forecast Cost of Therapy: INR 90 K (NSCLC), INR 3 Lac (Renal Cell Carcinoma)
Carfilzomib
Developer: Amgen
Indications: Multiple Myeloma
Patent Expiry: 2025
Therapy Duration: 14 cycles (13 months)
Dosing: Administered every 7 days in a cycle.
Cost (India):
- Per Vial: INR 25 K
- Total Cost of Therapy in 2024: INR 15 Lac
- Forecast Cost of Therapy: INR 5 Lac
Daratumumab
Developer: Jansen
Indications: Multiple Myeloma
Patent Expiry: 2026
Therapy Duration: 16 months
Dosing:
- Weeks 1-8: Weekly doses.
- Weeks 9-24: Once every two weeks.
- Week 25 onwards: Once a month.
Cost (India):
- Per Vial: INR 75 K / INR 18 K
- Total Cost of Therapy in 2024: INR 14.35 Lac
- Forecast Cost of Therapy: INR 4.75 Lac
Capmatinib
Developer: Novartis
Indications: Non-Small Cell Lung Cancer (NSCLC)
Patent Expiry: 2027
Therapy Duration: 12 months
Dosing: 400 mg twice daily.
Cost (India):
- Per Vial: INR 72 K
- Total Cost of Therapy in 2024: INR 35 Lac
- Forecast Cost of Therapy: INR 11.6 Lac
Nivolumab
Developer: BMS
Indications: NSCLC, Renal Cell Carcinoma, Head Neck Squamous Cell Carcinoma, Melanoma, Non-Hodgkin’s Lymphoma, Urothelial Cancer, Colorectal Cancer, Esophageal Squamous Cell Carcinoma, Gastric Cancer
Patent Expiry: 2026
Dosing:
- NSCLC: 3mg/kg every 2 weeks for 17 months.
- Renal Cell Carcinoma: 240 mg every 2 weeks for 5 months.
- Head Neck Squamous Cell Carcinoma: 2 months.
- Melanoma: 12 months.
- Non-Hodgkin’s Lymphoma: 6 months.
- Urothelial Cancer: 37 months.
- Colorectal Cancer: 25 months.
- Esophageal Squamous Cell Carcinoma: 6 months.
- Gastric Cancer: 7 months.
Cost (India):
- Per Vial: INR 84K / 38 K
- Total Cost of Therapy in 2024: Ranges from INR 5 Lac to INR 1.49 Cr depending on the indication.
- Forecast Cost of Therapy: Ranges from INR 1.6 Lac to INR 49.7 Lac.
Ripretinib
Developer: Deciphera
Indications: Gastrointestinal Stromal Tumor
Patent Expiry: 2027
Therapy Duration: 6 months
Dosing: 150 mg once daily.
Cost (India):
- Per Vial: INR 2.2 Lac
- Total Cost of Therapy in 2024: INR 13.6 Lac
- Forecast Cost of Therapy: INR 4.5 Lac
Conclusion
The biologics listed above, with their imminent patent expiries, present a golden opportunity for smaller pharmaceutical players to capitalize on the upcoming market shift. By investing in these molecules, companies can not only address unmet medical needs but also position themselves strategically in the competitive landscape of biologics. As we move through 2024, keeping an eye on these hidden gems could be the key to unlocking substantial market potential.
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